Interferon gamma (immune interferon) is an essential proinflammatory cytokine, produced in the human body by natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells. Receptors for interferon gamma are found in macrophages, neutrophils, natural killer cells and cytotoxic Т-lymphocytes. Activates effector functions of these cells, in particular, their microbicidity, cytotoxicity, production of cytokines, superoxide and nitrooxide radicals (thus causing death of intracellular parasites). Interferon gamma blocks replication of viral DNA and RNA, synthesis of virus proteins and assembly of mature virus particles. It causes cytotoxic effect on virus infected cells.
Inhibits b-cell-mediated response to interleukin-4, suppresses production of IgE and expression of CD23-antigen. Induces apoptosis of B-cells originating autoreactive clones. Disables suppressive effect of interleukin-4 to interleukin-2 depending proliferation and generation of lymphokine activated killers. Activates production of acute inflammation phase proteins C2 and C4 components of complement system.
Unlike other interferons, it increases I and II class major histocompatibility complex antigen expression, and induces expression of these molecules even on those cells that don't express them constitutively. Therefore, efficiency of antigen presentation and their ability to be recognized by Т-lymphocytes increases.
Interferon gamma blocks synthesis of β-TGF responsible for development of pulmonary and hepatic fibrosis.
Intranasally. Dissolve the vial content in 5 ml of water for injections.
In case of first signs of influenza or ARVI, 2 drops into each nasal passage after cleaning nasal passages 5 times a day for 5-7 days.
In order to prevent ARVI and influenza in case of contact with a sick person and/or exposure to cold, 2-3 drops into each nasal passage every second day 30 minutes before breakfast for 10 days. If necessary, preventive course may be repeated. In case of single contact, one dripping is enough.
It is recommended to massage the nose alae with fingers for a few minutes after dripping in order to distribute the drug in nasal cavity evenly.
Packaging set: 1 vial of drug, 1 vial of water for injection (5 ml) and 1 cap-dropper made of polyethylene in packaging of polyethylene or medical dropper in contour cellular package or in cassette contour package.
1 or 5 of contour package with application instructions are put into cardboard package.
1 or 5 vials of the drug respectively supplied with 1 or 5 cap-droppers made of polyethylene in packaging of polyethylene or medical dropper and with application instructions are put into cardboard package.
Manufacturer:
Pharmaklon RPE, LLC, Russia
Legal address:
30/34 Chekhov street, Serpukhov, Moscow region, Russia, 142200
Мanufacturer's address:
Biomed named after Mechnikov, Petrovo-Dalnee, Krasnogorsk district, Moscow region, Russia, 143422
Phone/fax:+7 (4967) 36-07-71, +7 (495) 120-12-47
E-mail: info@pharmaclon.ru
www.pharmaclon.ru